rhApo2L/TRAIL is a soluble recombinant human protein that targets pro-apoptotic death receptors 4 and 5 (DR4 and DR5), which are involved in the regulation of apoptosis (programmed cell death).  We are developing this product in collaboration with Genentech, Inc.

This information is current as of November 5, 2008. Amgen’s product pipeline will change over time as molecules move through the drug development process, including progressing to market or failing in clinical trials, due to the nature of the development process. This description contains forward-looking statements that involve significant risks and uncertainties, including those discussed in Amgen’s most recent Form 10-K and in Amgen’s periodic reports on Form 10-Q and Form 8-K, and actual results may vary materially. Amgen is providing this information as of the date above and does not undertake any obligation to update any forward-looking statements contained in this table as a result of new information, future events or otherwise.