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Amgen's First Research and Development Day Highlighted 24 of the Approximately 40 Programs in its Pipeline

Company Reported 14 Programs in Phase 2 or Phase 3 Clinical Development

Company Discussed 7 New Research and Development Programs in Inflammation,
Oncology or Pain Management and New Clinical Study Data from 3 Molecules

NEW YORK, March 23 -- Amgen Inc. (Nasdaq: AMGN), the world's largest biotechnology company, today held its first-ever Research and Development (R&D) review meeting. The company highlighted 24 programs that are currently in human clinical studies or are expected to enter human clinical studies in 2004. Overall, the company has approximately 40 programs in development, including 14 in Phase 2 or Phase 3. Seven programs in oncology, inflammation or pain management were discussed for the first time today along with new clinical data from three drug candidates.

"Our efforts over the last few years have resulted in significant increases in R&D productivity," said Kevin Sharer, Amgen's chairman and chief executive officer. "We continue to attract some of the industry's best and brightest scientists, encouraged by Amgen's R&D scope, capability, leadership and the commercial potential of our pipeline."

R&D at Amgen

Amgen's global R&D organization is focused on five therapeutic areas: inflammation, oncology, metabolic disease and osteoporosis, hematology and nephrology, and neurology.

As evidence of its increased R&D productivity, the company reported that more product candidates have entered into development at Amgen during the past three years than in the previous 10 years combined. In 2003, the company achieved 22 regulatory approvals worldwide. As of the end of last year, Amgen had more than thirty-five thousand patients enrolled in clinical studies. Pipeline expansion continues, as the company announced its intent to put as many as nine new programs into development in 2004.

"At Amgen we focus on grievous illnesses and hope to ameliorate them by developing truly innovative therapeutics," said Roger M. Perlmutter, M.D., Ph.D., executive vice president of Research and Development for Amgen. "Many of these potential molecules could create new treatment standards for people who suffer from debilitating illnesses."

Amgen's R&D organization follows four guiding principles: focus on grievous illness; be modality independent; understand efficacy in patients earlier; and ensure seamless integration from basic research through commercialization.

"To be successful, the commercialization process has to be a deeply collaborative one from the outset," said George Morrow, executive vice president of Global Commercial Operations for Amgen. "Together, we ask the questions: Is there a need in the marketplace? What unique benefits might the product offer? Can we advance the practice of medicine? Amgen is not interested in developing 'me-too' therapies, or treating diseases for which a number of effective treatments already exist."

Development Highlights

In discussing the pipeline, Amgen highlighted the commercial potential of select molecules and programs in clinical development. Click here for link to the informational chart:
A summary of products/programs discussed, including targeted 2004 milestones, is attached in Table 1.


Enbrel(R) (etanercept) has dramatically changed the way physicians treat inflammatory diseases. Amgen is committed to building on this success by developing additional therapeutics in this broad disease category. The company's research focus encompasses the major pathways involved in inflammatory diseases, including inhibition of pro-inflammatory cytokines, intracellular pathways and B-cell activation and differentiation. The company discussed seven programs in this disease area.

     Amgen reported on its marketed inflammation products Enbrel and
     Kineret® (anakinra).  Last year, Amgen and Wyeth Pharmaceuticals
     submitted a supplemental Biologics License Application (sBLA) for the use
     of Enbrel in the treatment of moderate to severe plaque psoriasis.
     Psoriasis, a disease characterized by chronic inflammation of the skin,
     affects nearly five million people in the U.S.  Amgen indicated that they
     expect to get approval for psoriasis in 2004.  Enbrel is already approved
     to treat rheumatoid arthritis, juvenile rheumatoid arthritis, psoriatic
     arthritis, and ankylosing spondylitis.

     Kineret, also indicated for the treatment of rheumatoid arthritis, was
     shown to relieve pain in a small pilot clinical study in the treatment of
     osteoarthritis.  Amgen announced that it plans to initiate a Phase 2
     clinical study with Kineret in osteoarthritis (OA) in 2004.

     AMG 108
     AMG 108 is a monoclonal antibody that blocks the action of Interleukin-1
     (IL-1), a cytokine that is believed to play a role in the joint
     destruction associated with OA.  In a Phase 1 clinical study, AMG 108
     administered subcutaneously (SC) was well-tolerated, and the clinical
     data suggests pharmaceutical properties consistent with infrequent
     dosing.  Phase 2 clinical studies are expected to begin in 2004.

     AMG 714
     AMG 714 is a human monoclonal antibody directed against Interleukin-15
     (IL-15) that is being developed under an agreement with Genmab S/A to
     treat inflammatory and autoimmune diseases.  AMG 714 is currently being
     evaluated in Phase 2 clinical studies for rheumatoid arthritis. Interim
     results suggest that AMG 714 may improve the signs and symptoms of
     rheumatoid arthritis.  Amgen expects to complete this Phase 2 clinical
     evaluation in 2004.

     p38 antagonist
     Amgen discussed its p38 antagonist small molecule program.  The p38 MAP
     kinase regulates a number of intracellular signaling pathways being
     targeted by Amgen. Inhibition of p38 kinase reduces expression of a
     variety of inflammatory mediators, including Tumor Necrosis Factor (TNF)
     and IL-1.  Amgen anticipates completing the Phase 1 clinical studies with
     a p38 antagonist in 2004.

     B-cell activating factor (BAFF) antagonist
     Amgen also discussed a B-cell activating factor (BAFF) antagonist program
     that reduces the production of abnormally functioning B-cells. This
     therapeutic target may have clinical utility in systemic lupus
     erythematosus and rheumatoid arthritis.  Amgen plans to initiate Phase 1
     clinical studies with a lead candidate from the BAFF antagonist program
     in 2004.
Metabolic Disease and Osteoporosis

Amgen also reported on its expanding research into metabolic disorders.

     Amgen discussed an 11B-HSD1 small molecule program that Amgen has
     exclusive rights to develop and commercialize based on an agreement with
     Biovitrum AB.  Small-molecule 11B-HSD1 enzyme inhibitors are being
     developed for the treatment of metabolic diseases, offering a unique
     mechanism that could potentially alter the therapy for type 2 diabetes.
     Additional clinical studies are planned in 2004.

Another area of focus for Amgen is osteoporosis, which results in significant economic burden on health care systems.

     AMG 162
     AMG 162 is Amgen's fully human monoclonal antibody that specifically
     targets the receptor activator of nuclear factor kappa B ligand (RANKL),
     a key mediator of the body's natural pathway of the resorptive phase of
     bone remodeling.  Amgen is the innovator of this biologic response
     modifier, one which may offer improved therapy for diseases associated
     with bone loss, like osteoporosis.  Intended to be administered twice-
     yearly through SC injections, AMG 162 has the potential to
     address key unmet patient and physician needs.   Amgen presented interim
     data from a Phase 2 clinical study demonstrating the clinical effect of
     AMG 162 on bone endpoints. Based on preliminary clinical data, AMG 162
     appears to be well-tolerated. Amgen anticipates the initiation of a Phase
     3 clinical study with AMG 162 in osteoporosis in 2004.

Amgen is building upon its heritage as a pioneer in science while leveraging its expertise in protein, antibody and small molecule research. Amgen's approach to oncology lies in its ability to identify, characterize and target novel proteins that are involved in cancer biology. These proteins often endow tumor cells with the activity to circumvent normal growth regulation. Amgen is focused on understanding these properties, which are common to many different types of cancer. In addition, Amgen is dedicated to providing cancer patients with supportive care products, which facilitate the ability to deliver chemotherapy and/or radiotherapy. The company discussed nine programs in this therapeutic area.

     AMG 162
     In addition to its potential use in osteoporosis, AMG 162 is being
     studied in metastatic bone disease for the suppression of bone loss in
     patients with cancer.  Amgen expects to initiate Phase 2 clinical studies
     of AMG 162 in metastatic bone disease in 2004.

     Palifermin is a recombinant human keratinocyte growth factor (rHuKGF)
     that appears to protect the epithelial cells lining the mouth and gut
     from damage caused by chemotherapy and/or radiotherapy.  It is being
     pursued for the treatment of oral mucositis, a painful condition
     characterized by severe mouth sores often requiring supplemental
     nutritional support.  This is one of the most debilitating side effects
     of cancer treatment.  Approximately four hundred thousand patients in the
     U.S. suffer from mucositis during cancer treatment, with no effective
     standard therapy available.  Amgen confirmed plans to submit marketing
     applications in the United States and Europe in 2004 for palifermin in
     the bone marrow transplant setting.

     Neulasta® and Aranesp®
     Amgen discussed the continuing development of supportive care oncology
     products Neulasta® (pegfilgrastim), Amgen's once-per-cycle product for
     decreasing the incidence of infections associated with many types of
     cancer chemotherapy treatments, and Aranesp® (darbepoetin alfa), its
     latest product for the treatment of anemia associated with chronic kidney
     disease and chemotherapy-induced anemia. Neulasta clinical studies are
     focused on first-cycle use in patients with moderate risk for febrile
     neutropenia, support of dose-dense chemotherapy, and the development of
     methods to identify patients at risk of developing febrile neutropenia
     who should benefit from prophylactic use of Neulasta.

     Aranesp's continued development includes clinical studies using less
     frequent dosing as well as therapeutic trials in patients suffering from
     the anemia of cancer.

     AMG 114
     AMG 114 is a hyperglycosylated analog of Aranesp, which has shown greater
     in vivo potency than epoetin alfa or darbepoetin alfa in preclinical
     studies and is being developed to treat chemotherapy-induced anemia.
     Amgen expects to initiate Phase 1/2 clinical studies with AMG 114 in

     Panitumumab (rHuMAb-EGFr) is the first fully human monoclonal antibody
     directed against the epidermal growth factor receptor (EGFr).  It is
     being evaluated as monotherapy and in combination with other agents for
     the treatment of various solid tumor cancers in partnership with Abgenix,
     Inc.  In 2004, Amgen initiated pivotal clinical studies in panitumumab as
     a third-line monotherapy in colorectal cancer patients with a convenient
     every-other-week dosing regimen.

     Amgen discussed the Apo2L/TRAIL molecule that they are developing in
     collaboration with Genentech, Inc. Apo2L/TRAIL is a soluble human protein
     involved in the regulation of apoptosis, also known as programmed cell
     death. Amgen and Genentech anticipate initiation of Phase 1 clinical
     studies with Apo2L/TRAIL in the third quarter of 2004.

     AMG 706
     Amgen introduced its small molecule angiogenesis inhibitor, AMG 706,
     which selectively inhibits multiple kinases.  Amgen is encouraged by
     early clinical data that show signs of tumor regression, along with
     promising preliminary data that potentially allow for combination
     therapy.  Amgen expects to complete a Phase 1 clinical study with AMG 706
     in 2004.

     Angiopoietin (ANG) Receptor Antagonist
     Amgen also discussed its Angiopoietin (ANG) Receptor Antagonist program.
     This novel molecule inhibits tumor growth and reduces the viable tumor
     fraction in preclinical models.  Amgen expects to initiate Phase 1
     clinical studies with a lead ANG antagonist candidate from this program
     in 2004.
Hematology and Nephrology

Amgen has a proven track record in hematology with its work in discovering, developing and marketing products such as Epogen® (epoetin alfa), Neupogen® (filgrastim), Aranesp and Neulasta. Amgen reported on its further development efforts with Aranesp in the chronic kidney disease patient population with the planned initiation in 2004 of the Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT).

Amgen presented associative data suggesting that congestive heart failure (CHF) patients with low hemoglobin levels are at increased risk for death (all-cause mortality). Amgen discussed plans to complete enrollment in an Aranesp Phase 2 study in anemic CHF patients in 2004.

     Amgen reported on alfimeprase, a modified fibrolase that directly
     degrades fibrin when delivered through a catheter at the site of a blood
     clot, which is being developed in collaboration with Nuvelo.  Alfimeprase
     is currently in a Phase 2 clinical study in patients with peripheral
     arterial occlusion (PAO).  PAO occurs when a clot blocks arterial blood
     flow to an extremity.  Phase 2 alfimeprase clinical studies in patients
     with PAO are expected to be completed in 2004.

     AMG 531
     AMG 531 is a first-in-class molecule with a novel mechanism of action in
     Phase 2 clinical development for the treatment of immune (idiopathic)
     thrombocytopenic purpura (ITP), a serious unmet need.  ITP is an
     autoimmune bleeding disorder characterized by an insufficient number of
     platelets; specialized blood cells that help prevent and stop bleeding.
     There are approximately seventy thousand adult patients diagnosed in the
     U.S. with ITP.  Unlike current therapies, AMG 531 stimulates platelet
     production.  Amgen anticipates completing Phase 2 clinical studies with
     AMG 531 in 2004.

     Sensipar(TM) (cinacalcet HCl) is a first-in-class oral calcimimetic,
     recently approved by the FDA for once-daily administration in patients
     with secondary hyperparathyroidism (HPT) on dialysis and for the
     treatment of elevated levels of calcium in patients with parathyroid
     cancer.  Secondary HPT in patients with chronic kidney disease on
     dialysis affects approximately three hundred thirty-five thousand
     patients in the U.S. and an additional two hundred twenty thousand
     patients in Europe. Sensipar is the only available treatment that may
     enable patients to simultaneously achieve target levels of PTH, calcium,
     phosphorus and calcium-phosphorus product as recommended in the Kidney
     Disease Outcomes Quality Initiative (K/DOQI) clinical practice guidelines
     recently issued by the National Kidney Foundation.  Amgen licensed
     Sensipar from NPS Pharmaceuticals Inc. in 1996.

Amgen reported on its neurology program, which is focused on discovering and developing therapeutics targeting neurodegenerative diseases such as Parkinson's Disease. For the first time, Amgen revealed research efforts into novel neuropathic and inflammatory pain therapeutics.

     Nerve Growth Factor (NGF) antagonist
     Amgen highlighted the company's Nerve Growth Factor (NGF) antagonist
     program targeting neuropathic pain, an often long-lasting debilitating
     condition associated with diabetic and post-herpetic neuropathy.  Painful
     diabetic neuropathy is the most common neuropathic condition, affecting
     approximately five million diabetics in the U.S. alone.  Several
     approaches are being explored to target NGF, including a neurotrophic
     factor that controls expression of pain mediators in nerve terminals
     Amgen anticipates completing the Phase 1 clinical study for the NGF
     program in 2004

     Vanilloid Receptor 1 (VR1) antagonist
     Amgen also discussed a Vanilloid Receptor 1 (VR1) antagonist small
     molecule program. VR1 is a receptor found in pain-sensing nerves
     Preclinical results demonstrate long-lasting relief of inflammatory pain
     Approximately fifty million people in the U.S. suffer from chronic pain
     and pain is the number one reason people seek health care treatment
     About 40 percent of people with moderate to severe pain are unable to
     achieve adequate pain relief.  Amgen anticipates initiating Phase 1
     clinical studies with a VR1 antagonist in 2004

     Glial cell derived neurotrophic factor (GDNF)
     Glial cell derived neurotrophic factor (GDNF) is currently in Phase 2
     placebo-controlled clinical studies in patients with advanced Parkinson's
     Disease.  There are over one million patients diagnosed with Parkinson's
     Disease in the U.S.; approximately 15 percent are severely disabled. GDNF
     is a naturally-occurring protein. Preclinical data suggest that GDNF both
     protects and stimulates regeneration of neurons that secrete dopamine
     the same neurons that are progressively lost in Parkinson's Disease
     Amgen has developed a recombinant protein analogue of naturally occurring
     GDNF, a potential first-in-class breakthrough therapy for advanced
     Parkinson's Disease
     An open label clinical study of GDNF with five patients showed sustained
     and progressive improvement in motor function and increased neuronal
     fluorodopa uptake.  Phase 2 clinical studies with GDNF in advanced
     Parkinson's Disease patients are expected to be completed in 2004.
    Table 1

                              Molecule/Program            Targeted
                                                          Milestones in 2004


    Inflammation              Enbrel®                   Approval for

                              Kineret(R)                  Initiate Phase 2 -

                              AMG 108                     Initiate Phase 2 -

                              AMG 714                     Complete Phase 2 -

                              p38 Antagonist              Complete Phase 1

                              BAFF Antagonist             Initiate Phase 1


    Metabolic and             11B-HSD1                    Initiate
    Osteoporosis                                          Additional Studies

                              AMG 162                     Initiate Phase 3 -


    Oncology                  AMG 162                     Initiate Phase 2 -
                                                          Metastatic Bone

                              Palifermin                  US/EU Mucositis
                                                          BMT Filing

                              Neulasta®                 Complete Moderate
                                                          Risk Febrile
                                                          Neutropenia Study

                              Aranesp®                  Initiate Extended
                                                          Dosing Study -
                                                          Induced Anemia

                              AMG 114                     Initiate Phase 1/2
                                                          - Chemotherapy-
                                                          Induced Anemia

                              Panitumumab                 Enroll Pivotal
                                                          Study - Colorectal

                              Apo2L/TRAIL                 Initiate Phase 1

                              AMG 706                     Complete Phase 1

                              Receptor Antagonist         Initiate Phase 1


    Hematology and            Aranesp®                  Initiate TREAT
    Nephrology                                            Outcomes Study -
                                                          Chronic Kidney

                              Aranesp®                  Enroll Phase 2 -
                                                          Congestive Heart

                              Alfimeprase                 Complete Phase 2 -
                                                          Arterial Occlusion

                              AMG 531                     Complete Phase 2 -

                              Sensipar™                Launch


    Neurology                 NGF Antagonist              Complete Phase 1

                              VR1 Antagonist              Initiate Phase 1

                              GDNF                        Complete Phase 2 -

    Financial Discussion

The company also indicated that the following long-term guidance provided at its Business Review Meeting held in February 2003 remains achievable: the company expected product sales to increase at a compound annual growth rate in the 30 to 32 percent range during the 2002 through 2005 time period and expected adjusted earnings per share to grow in the 25 to 27 percent range for the same period. The company stated that these growth rates assume no acquisitions or product in-licensing and that its present understanding of Medicare reimbursement changes remains limited.

Adjusted earnings per share for the period 2002 through 2005 exclude certain expenses related to the acquisition of Immunex and certain non- recurring items. These expenses and non-recurring items are reconciled in the reconciliation table below.


This news release contains forward-looking statements that involve significant risks and uncertainties, including those discussed below and others that can be found in Amgen's Form 10-K for the year ended December 31, 2003, and in Amgen's periodic reports on Form 10-Q and Form 8-K. Amgen is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise.

No forward-looking statement can be guaranteed and actual results may differ materially from those we project. Discovery or identification of new product candidates or development of new indications for existing products cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate or development of a new indication for an existing product will be successful and become a commercial product. Further, preclinical results do not guarantee safe and effective performance of product candidates in humans. The complexity of the human body cannot be perfectly, or sometimes, even adequately modeled by computer or cell culture systems or animal models. The length of time that it takes for us to complete clinical trials and obtain regulatory approval for product marketing has in the past varied and we expect similar variability in the future. We develop product candidates internally and through licensing collaborations, partnerships and joint ventures. Product candidates that are derived from relationships may be subject to disputes between the parties or may prove to be not as effective or as safe as we may have believed at the time of entering into such relationship. Also, we or others could identify side effects or manufacturing problems with our products after they are on the market. In addition, sales of our products are affected by the availability of reimbursement and the reimbursement policies imposed by third party payors, including governments, private insurance plans and managed care providers, and may be affected by domestic and international trends toward managed care and healthcare cost containment as well as possible U.S. legislation affecting pharmaceutical pricing and reimbursement. Government regulations and reimbursement policies may affect the development, usage and pricing of our products. In addition, we compete with other companies with respect to some of our marketed products as well as for the discovery and development of new products. We believe that some of our newer products, product candidates or new indications for existing products, may face competition when and as they are approved and marketed. Our products may compete against products that have lower prices, established reimbursement, superior performance, are easier to administer, or that are otherwise competitive with our products. In addition, while we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors and there can be no guarantee of our ability to obtain or maintain patent protection for our products or product candidates. We cannot guarantee that it will be able to produce commercially successful products or maintain the commercial success of our existing products. Our stock price may be affected by actual or perceived market opportunity, competitive position, and success or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations.

The scientific information discussed in this presentation related to our product candidates is preliminary and investigative. Such product candidates are not approved by the U.S. Food and Drug Administration (FDA), and no conclusions can or should be drawn regarding the safety or effectiveness of the product candidates. Only the FDA can determine whether the product candidates are safe and effective for the uses being investigated. Further, the scientific information discussed in this presentation relating to new indications for our approved products is preliminary and investigative and is not part of the labeling approved by the FDA for the products. Healthcare professionals should refer to and rely upon the FDA-approved labeling for the products, and not the information discussed in this presentation.

Amgen is a global biotechnology company that discovers, develops, manufactures and markets important human therapeutics based on advances in cellular and molecular biology.

    Amgen Inc.
    Reconciliation of GAAP (loss) earnings per share to "Adjusted" earnings
      per share
    (In millions, except per share data)

                                    Historical results  Implied results
                                      for year ended     for year ended
                                        12/31/2002         12/31/2005
     GAAP (loss) earnings per share        $(1.21)      $2.55 - $2.69

     Adjustments to GAAP (loss) earnings
      per share:
      Write-off of acquired in-process
       research and development              2.53 (1)              --
      Amortization of acquired
       intangible assets                     0.12 (1)            0.16 (1)
      Other merger related expenses          0.06 (1)              --
      Litigation settlement                 (0.12)                 --
      Amgen Foundation contribution          0.03                  --
      Termination of collaboration
       agreements                           (0.03)                 --
     "Adjusted" earnings per share          $1.38       $2.71 - $2.85

      Adjustment for interest expense
       on convertible notes                 $0.01 (2)             $--

     "Adjusted" earnings per share          $1.39 (3)   $2.71 - $2.85

     (1)  Incurred in connection with the Immunex acquisition in July 2002.

     (2)  Pursuant to the if-converted method of calculating EPS, the
          numerator for "Adjusted" EPS in 2002 reflects the avoidance of
          interest expense incurred, net of tax, related to the assumed
          conversion of the convertible notes.  The conversion of such debt
          and the avoidance of interest expense is not assumed for calculating
          the GAAP EPS because its impact is anti-dilutive due to the GAAP net
          loss in 2002.

     (3)  Due to the GAAP net loss in 2002, shares used in calculating the
          GAAP loss per share exclude the impact of stock options and
          convertible notes because their impact was anti-dilutive.  Shares
          used in calculating the "Adjusted" earnings per share for 2002
          include the impact of dilutive stock options (27.1 million shares)
          and convertible notes (29.3 million shares) under the treasury stock
          and "if-converted" methods, respectively.

     Amgen Inc.
     Summary reconciliation of "Adjusted" EPS CAGR to GAAP EPS CAGR
     For the 2002-2005 period
     "Adjusted" EPS CAGR (Guidance)                   25% - 27%
     GAAP EPS CAGR                                         N/A (1)

     (1) Due to the GAAP loss per share of ($1.21) in 2002, a GAAP EPS CAGR
     for the 2002-2005 period cannot be calculated.

Amgen, Thousand Oaks
Sabrina Johnson, (805) 447-4587 (media)
Cary Rosansky, (805) 447-1060 (investors)