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Mats Wikstrom

Principal Scientist
Process Development

Mats has extensive research, development, and management experience from academic research and the pharmaceutical industry after assignments at universities, institutes and companies such as Lund University, Sweden, the National Institutes of Health (NIH), United States, the Pharmacia and Upjohn Company, Sweden/United States, the Biovitrum Company, the Karolinska Institute, Sweden, and the University of Copenhagen, Denmark. His primary research interest has been focused on deciphering the molecular details in protein-protein interactions with emphasis on the complex interplay in host-pathogen interactions in the area of infectious diseases. A great deal of his work has been devoted to the structural and functional elucidations of surface-associated proteins on pathogens. For instance, his work resulted in the discovery of a novel secreted virulence determinant from Streptococcus pyogenes including full structural, functional and clinical characterization. Mats currently leads the Higher Order Structure (HOS) group at Amgen, Thousand Oaks, providing biophysical characterization support for the development and marketing of Amgen's biopharmaceutical products.

Featured Publications

Wen, J., Batabyal, D., Knutson, N., Lord, H., Wikström, M. A Comparison Between Emerging and Current Biophysical Methods for the Assessment of Higher-Order Structure of Biopharmaceuticals. J. Pharm. Sciences 2020, 109: 247-253. https://jpharmsci.org/article/S0022-3549(19)30663-X/pdf

Happonen, L., Hauri, S., Svensson Birkedal, G, Karlsson, C., de Neergaard, T, Khakzad, H, Nordenfelt, P, Wikström, M., Wisniewska, M., Björck, L., Malmström, L., and Malmström, J. A quantitative Streptococcus pyogenes-human protein-protein interaction map. Nature Communications 2019: 10; 2727. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588558/pdf/41467_2019_Article_10583.pdf

Brinson et al. and Wikström, M. Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics. MAbs 2019; 11:94-105. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343768/pdf/kmab-11-01-1544454.pdf

Diehl C, Akke M, Mailand N, Streicher W, Wikström M. Structural Analysis of a Complex between Small Ubiquitin-like Modifier 1 (SUMO1) and the ZZ Domain of CREB-binding Protein (CBP/p300) Reveals a New Interaction Surface on SUMO. J. Biol. Chem. 2016; 291: 12658-12672. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933466/pdf/zbc12658.pdf

Wisniewska M, Happonen L, Varjosala V, Malmström L, Rosenberger J, Pozdnyakova I, Frick IM, Björck L, Streicher W, Malmström J, Wikström M. Functional and Structural Properties of a Novel Protein and Virulence Factor (Protein sHIP) in Streptococcus pyogenes. J. Biol. Chem. 2014; 289: 18175-18188. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140258/pdf/zbc18175.pdf

Education

Postdoctoral Research Fellowship, National Institutes of Health (NIH), Bethesda, MD
Associate Professor, Biophysical Chemistry, Lund University, Sweden
Ph.D., Biophysical Chemistry, Lund University, Sweden
M.Sc., Biophysics, Umea University, Sweden