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Nate Joh

Senior Scientist
Process Development

Nate joined Amgen in 2016. He is currently a Sr. Scientist in the Attribute Sciences Department where he leads investigations to understand the physicochemical characteristics and biological impacts of protein drug molecule variants referred to as attributes. In addition, Nate has founded working groups to develop methods for analyzing the clinical impact of attributes and to perform attribute structure determination. Prior to working at Amgen, he developed a higher-throughput method for measuring the thermodynamic stability of therapeutic proteins at Bayer HealthCare in Berkeley, CA, as a Development Scientist.

Nate received his PhD in Biochemistry and Molecular Biology at UCLA where he was trained in structural biology, informatics and protein folding. Subsequently, he assumed NIH postdoctoral fellowship at UPenn and UCSF where he performed computational protein design and biophysical experiments.

Featured Publications

Joh NH*, Thomas L, Christian TR, Verlinsky A, Jiao N, Allotta N, Jawa V, Cao S, Narhi LO, Joubert MK*. "Silicone Oil Particles in Prefilled Syringes with Human Monoclonal Antibody Representative of Real-World Drug Products Did Not Increase Immunogenicity in In Vivo and In Vitro Model Systems" J Pharm Sci. 2019 Oct 16 online *Co-corresponding Authors https://pubmed.ncbi.nlm.nih.gov/31628922/

Joh NH*, Grigoryan G, Wu Y, DeGrado WF*. "Design of self-assembling transmembrane helical bundles to elucidate principles required for membrane protein folding and ion transport" Philos Trans R Soc Lond B Biol Sci 2017 Aug 5; 372(1726) *Co-corresponding Authors https://pubmed.ncbi.nlm.nih.gov/28630154/

Joh NH, Wang T, Bhate M, Acharya R, Wu Y, Grabe M, Hong M, Grigoryan G, DeGrado WF. "De Novo Design of a transmembrane Zn2+ transporting four-helix bundle" Science 2014 Dec 19; 346(6216):1520-4 https://pubmed.ncbi.nlm.nih.gov/25525248/

Joh NH, Oberai A, Yang D, Whitelegge JP, Bowie JU. "Similar energetic contributions of packing in the core of membrane and water soluble proteins" JACS 2009 Aug 12; 131(31):10846-7 Epub 2009 Jul 15 https://pubmed.ncbi.nlm.nih.gov/19603754/

Joh NH, Min A, Faham S, Whitelegge JP, Yang D, Woods VL Jr, Bowie JU. "Modest stabilization by most hydrogen-bonded side-chain interactions in membrane proteins"Nature 2008 Jun 26; 453(7199): 1266-70 Epub 2008 May 25 https://pubmed.ncbi.nlm.nih.gov/18500332/

Education

NIH Postdoctoral Fellowship, University of Pennsylvania and University of California- San Francisco
Ph.D., Biochemistry and Molecular Biology, University of California- Los Angeles
B.S., Chemistry, California State Polytechnic University Pomona