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Paul Hughes

Scientific Director
Oncology Research

Paul joined Amgen-Thousand Oaks in 2003 as a Scientist in Oncology Research. Prior to Amgen, Paul completed his post-doctoral work at Scripps Research Institute in La Jolla. Paul’s research interest is largely focused on the discovery of novel small molecule oncology therapeutics. Areas of focus include supporting Amgen’s portfolio of clinical stage Mcl-1 inhibitors and working in cross-functional teams to develop novel targeted therapies focused on drugging proteins that are genetically altered in cancer. Paul also works closely with colleagues in business development to identify opportunities to in-license exciting innovation discovered outside of Amgen. He’s also responsible for several collaborations with teams at leading academic research groups.

Featured Publications

Caenepeel S, Brown SP, Belmontes B, Moody G, Keegan KS, Chui D, Whittington DA, Huang X, Poppe L, Cheng AC, Cardozo M, Houze J, Li Y, Lucas B, Paras NA, Wang X, Taygerly JP, Vimolratana M, Zancanella M, Zhu L, Cajulis E, Osgood T, Sun J, Damon L, Egan RK, Greninger P, McClanaghan JD, Gong J, Moujalled D, Pomilio G, Beltran P, Benes CH, Roberts AW, Huang DC, Wei A, Canon J, Coxon A, Hughes PE. AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies. Cancer Discov. 2018 Dec;8(12):1582-1597. doi: 10.1158/2159-8290.CD-18-0387. Epub 2018 Sep 25. Erratum in: Cancer Discov. 2019 Jul;9(7):980. PMID: 30254093. https://pubmed.ncbi.nlm.nih.gov/30254093/

Nangia V, Siddiqui FM, Caenepeel S, Timonina D, Bilton SJ, Phan N, Gomez-Caraballo M, Archibald HL, Li C, Fraser C, Rigas D, Vajda K, Ferris LA, Lanuti M, Wright CD, Raskin KA, Cahill DP, Shin JH, Keyes C, Sequist LV, Piotrowska Z, Farago AF, Azzoli CG, Gainor JF, Sarosiek KA, Brown SP, Coxon A, Benes CH, Hughes PE, Hata AN. Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non-Small Cell Lung Cancer. Cancer Discov. 2018 Dec;8(12):1598-1613. doi: 10.1158/2159-8290.CD-18-0277. Epub 2018 Sep 25. PMID: 30254092; PMCID: PMC6279543. https://pubmed.ncbi.nlm.nih.gov/30254092/

Hughes PE, Caenepeel S, Wu LC. Targeted Therapy and Checkpoint Immunotherapy Combinations for the Treatment of Cancer. Trends Immunol. 2016 Jul;37(7):462-476. doi: 10.1016/j.it.2016.04.010. Epub 2016 May 20. PMID: 27216414. https://pubmed.ncbi.nlm.nih.gov/27216414/

Hughes PE, Rex K, Caenepeel S, Yang Y, Zhang Y, Broome MA, Kha HT, Burgess TL, Amore B, Kaplan-Lefko PJ, Moriguchi J, Werner J, Damore MA, Baker D, Choquette DM, Harmange JC, Radinsky R, Kendall R, Dussault I, Coxon A. In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models. Mol Cancer Ther. 2016 Jul;15(7):1568-79. doi: 10.1158/1535-7163.MCT-15-0871. Epub 2016 Apr 19. PMID: 27196782. https:/pubmed.ncbi.nlm.nih.gov/27196782/

Education

Postdoctoral Fellowship, Scripps Research Institute
D.Phil. (Ph.D. equivalent), Molecular Biology, University of Oxford
B.S., Biochemistry, University of Sussex