fellows_sally_yu_shi

Sally joined Amgen in 2016 as a postdoctoral fellow to study the molecular interaction of endocrine fibroblast growth factors (FGFs) with their receptors. She is currently a scientist in the Department of Cardiometabolic Disorders pursuing early target discovery. Her research focuses on cardiovascular and metabolic disease areas with large unmet need. Part of Sally’s current research interests is to leverage single-cell technologies and in vivo animal models to understand the role of cardiac interstitial cells in the pathogenesis of heart failure, with the goal of translating research findings into effective therapies.

Featured Publications

Shi SY, Luo X, Yamawaki TM, Li CM, Ason B, Furtado MB. Recent Advances in Single-Cell Profiling and Multispecific Therapeutics: Paving the Way for a New Era of Precision Medicine Targeting Cardiac Fibroblasts. Curr Cardiol Rep. 2021 Jun 3;23(7):82. 
https://pubmed.ncbi.nlm.nih.gov/34081224/

Shi SY, Lu YW, Richardson J, Min X, Weiszmann J, Richards WG, Wang Z, Zhang Z, Zhang J, Li Y. A systematic dissection of sequence elements determining β-Klotho and FGF interaction and signaling. Sci Rep. 2018 Jul 23;8(1):11045.
https://pubmed.ncbi.nlm.nih.gov/30038432/

Shi SY, Lu YW, Liu Z, Stevens J, Murawsky CM, Wilson V, Hu Z, Richards WG, Michaels ML, Zhang J, Yan W, Li Y. A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activity. J Biol Chem. 2018 Apr 20;293(16):5909-5919.
https://pubmed.ncbi.nlm.nih.gov/29483191/

Shi SY, Lu SY, Sivasubramaniyam T, Revelo XS, Cai EP, Luk CT, Schroer SA, Patel P, Kim RH, Bombardier E, Quadrilatero J, Tupling AR, Mak TW, Winer DA, Woo M. DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice. Nat Commun. 2015 Jun 16;6:7415.
https://pubmed.ncbi.nlm.nih.gov/26077864/ 

Luck H, Tsai S, Chung J, Clemente-Casares X, Ghazarian M, Revelo XS, Lei H, Luk CT, Shi SY, Surendra A, Copeland JK, Ahn J, Prescott D, Rasmussen BA, Chng MH, Engleman EG, Girardin SE, Lam TK, Croitoru K, Dunn S, Philpott DJ, Guttman DS, Woo M, Winer S, Winer DA. Regulation of obesity-related insulin resistance with gut anti-inflammatory agents. Cell Metab. 2015 Apr 7;21(4):527-42.  
https://pubmed.ncbi.nlm.nih.gov/25863246/

Education

Postdoctoral Fellowship, Amgen
Ph.D., University of Toronto
B.Sc., University of Toronto