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Xin Yu

Senior Scientist
Oncology Research

Xin joined Amgen in 2015 as a Scientist in Inflammation and Oncology Research. In 2019, Xin became a Senior Scientist because of her significant contributions in scientific research and drug development. Prior to that, she spent seven years at Genentech to drive the discovery and development of therapeutic targets in both autoimmune diseases and cancer immunotherapy, with primary focus on modulating T cell responses for disease intervention. Xin is one of the pioneers to identify TIGIT as a T cell co-inhibitory receptor and she is the first author on the first TIGIT paper published in 2009 Nature Immunology. 

Xin’s current basic research interest at Amgen aims to explore the mechanisms of how tumor microenvironment impacts antitumor immunity. The network crosstalk in tumor microenvironment among tumor cells, tumor associated stroma, tumor infiltrating immune populations, and endothelial cells in tumor, via metabolites, cytokine/chemokines, and costimulatory/coinhibitory receptors, is important in regulating antitumor effector T cell activity. Xin’s group endeavors to understand the key modulatory pathways and players in tumor microenvironment to provide insights for new target identification and novel therapeutic strategy development.

Featured Publications

Xin Yu*, Lei Zhang, Ashutosh Chaudhry, Aaron S. Rapaport, Wenjun Ouyang*. (2020) Unravelling the heterogeneity and dynamic relationships of tumor-infiltrating T cells by single-cell RNA sequencing analysis. J Leukoc Biol 107:917-932. (Review) (* co-corresponding authors) https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.6MR0320-234R

Lei Zhang, Ziyi Li, Katarzyna M. Skrzypczynska, Qiao Fang, Wei Zhang, Sarah A. O’Brien, Yao He, Lynn Wang, Qiming Zhang, Aeryon Kim, Ranran Gao, Jessica Orf, Tao Wang, Deepali Sawant, Jiajinlong Kang, Dev Bhatt, Daniel Lu, Chi-Ming Li, Aaron S. Rapaport, Kristy Perez, Yingjiang Ye, Shan Wang, Xueda Hu, Xianwen Ren, Wenjun Ouyang, Zhanlong Shen,* Jackson G. Egen,* Zemin Zhang,* and Xin Yu* (2020) Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer. Cell 181:442-459. (* co-corresponding authors) https://www.sciencedirect.com/science/article/pii/S009286742030341X?via%3Dihub

Aeryon Kim, Chia-Jung Han, Ian Driver, Aleksandra Olow, Andrew K. Sewell, Zemin Zhang, Wenjun Ouyang, Jackson G. Egen, Xin Yu. (2019) LILRB1 Blockade Enhances Bi-specific T Cell Engager Antibody-Induced Tumor Cell Killing by Effector CD8+ T Cells. J Immunol 203:1076-1087. https://www.jimmunol.org/content/early/2019/06/27/jimmunol.1801472

Lei Zhang*, Xin Yu*, Liangtao Zheng*, Yuanyuan Zhang*, Yansen Li, Qiao Fang, Ranran Gao, Boxi Kang, Qiming Zhang, Julie Y. Huang, Hiroyasu Konno, Xinyi Guo, Yingjiang Ye, Songyuan Gao, Shan Wang, Xueda Hu, Xianwen Ren, Zhanlong Shen, Wenjun Ouyang & Zemin Zhang (2018) Lineage tracking reveals dynamic relationships of T cells in colorectal cancer. Nature 564:268-272. (* These authors contribute equally to this work) https://www.nature.com/articles/s41586-018-0694-x?draft=collection

Xin Yu, Kristin Harden, Lino C Gonzalez, Michelle Francesco, Eugene Chiang, Bryan Irving, Irene Tom, Sinisa Ivelja, Canio J Refino, Hilary Clark, Dan Eaton & Jane L Grogan (2009). The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol 10:48-57. https://www.nature.com/articles/ni.1674

Education

Ph.D., Molecular Immunology, UT Southwestern Medical Center, Dallas, TX
B.S., Basic Medicine (M.D. equivalent), Peking University Medical School, Beijing, China