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Yen-Sin Ang

Scientist
Cardiometabolic Disorders

Yen-Sin joined Amgen in 2017 to pursue early target discovery in the department of Cardiometabolic Disorders. His current research focuses on the characterization of novel genetically validated targets regulating patho-mechanisms of atrial fibrillation and heart failure. He has a strong interest to integrate systems biology with genome-edited pluripotent stem cells, bioengineering technologies and mouse models to better understand human disease; which is required to develop innovative medicines to serve patients. Apart from drug discovery, Yen-Sin is passionate about training the next generation of biomedical scientists and is presently a co-mentor with UCSF faculty, Dr. Vasanth Vedantham. Together, they are investigating the architecture and function of the sinoatrial node in the regulation of cardiac rhythm and contractility.

Featured Publications

Ang YS, Rajamani S, Haldar S, Huser J. A New Therapeutic Framework for Atrial Fibrillation Drug Development. Circulation Research. 2020; 127:184–201 https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.120.316576

Ang YS, Rivas R, Ribeiro A, Srivas R, Pratt K, Stone N, Mohamed T, Spencer I, Fu JD, Tippens N, Radzinsky E, Li M, Narasimha A, Moon-Grady M, Yu H, Pruitt B, Snyder M, Srivastava D. Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis. Cell. 2016 Dec 15;167(7):1734-1749.e22 https://www.cell.com/cell/pdf/S0092-8674(16)31605-1.pdf

Mohamed T, Ang YS, Radzinsky E, Zhou P, Huang Y, Elfenbein A, Foley A, Magnitsky S, Srivastava D. Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration. Cell. 2018 Mar 22;173(1):104-116.e12. https://www.cell.com/cell/pdf/S0092-8674(18)30158-2.pdf

Ang YS#, Tsai SY, Lee DF, Monk J, Su J, Ratnakumar K, Ding J, Ge Y, Darr H, Chang B, Wang J, Rendl M, Bernstein E, Schaniel C, Lemischka IR. Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell. 2011; 145:183-197 (#co-corresponding) https://www.cell.com/fulltext/S0092-86741100240-6

Miranda KC*, Huynh T*, Tay Y*, Ang YS*, Tam WL, Thomson AM, Lim B, Rigoutsos I. A pattern-based method for the identification of microRNA binding sites and their corresponding heteroduplexes. Cell. 2006; 126:1203-1217(*co-first) https://pubmed.ncbi.nlm.nih.gov/16990141/

Education

Post-Doctoral Fellowship, Gladstone Institutes & University of California- San Francisco
Ph.D., Mount Sinai School of Medicine
B.Sc., National University of Singapore