"The brodalumab data being presented at EULAR demonstrate a positive benefit-risk profile for patients with psoriatic arthritis," said
Based on the Phase 2 results, the companies intend to advance brodalumab into Phase 3 clinical studies for the treatment of psoriatic arthritis in 2014.
"This brodalumab data marks a positive step forward for patients with psoriatic arthritis," said Dr.
ABSTRACT OF INTEREST:
Brodalumab Abstract at EULAR:
Abstracts are currently available on the EULAR website at www.eular.org.
Brodalumab is a highly-selective human monoclonal antibody that binds to and blocks signaling via the IL-17 receptor. The IL-17 pathway plays an important role in inducing and promoting inflammatory disease processes.
Brodalumab is the first investigational treatment in development that blocks the IL-17 receptor, thereby blocking several of the IL-17 ligands at once. By stopping IL-17 ligands from binding to the receptor, brodalumab prevents the body from receiving signals that may lead to inflammation and other ailments. At this time, other agents in development seek to target a single IL-17 ligand.
In addition to psoratic arthritis, brodalumab is currently being investigated for the treatment of psoriasis (Phase 3) and asthma (Phase 2).
About Psoriatic Arthritis
Psoriatic arthritis is a chronic disease of the immune system that causes joint pain, stiffness and swelling which can become progressively worse over time, and may also include red patches of skin topped with silvery scales.1
The progressive joint damage, pain and swelling coupled with painful, scaly, red skin patches can disrupt a person's ability to perform daily activities, such as using their hands, standing for long periods or walking.2 Psoriatic arthritis affects 30 to 50 percent3 of the approximate 125 million people worldwide who have psoriasis.4
Amgen Forward-Looking Statements
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The scientific information discussed in this news release related to our product candidate is preliminary and investigative. Such product candidate is not approved by the U.S. Food and Drug Administration (
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Ashleigh Koss, 805-313-6151 (media)
Arvind Sood, 805-447-1060 (investors)
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1Krueger, Gerald G., MD. Clinical Features of Psoriatic Arthritis. The American Journal of Managed Care. 2002; 8:160-170
2Krueger G, Koo J, Lebwohl M, et al. The Impact of Psoriasis on Quality of Life: Results of a 1998 National Psoriasis Foundation Patient-Membership Survey. Arch Dermatol. 2001; 137:280-4
3International Federation of Psoriasis Associations, Important facts about psoriasis http://www.ifpa-pso.org/web/page.aspx?refid=47
4About Psoriasis: Statistics. National Psoriasis Foundation. http://www.psoriasis.org/learn_statistics