Dr. Thomas Quertermous is currently the William G. Irwin Professor of Medicine and Director of the Research in the Division of Cardiovascular Medicine at Stanford University. Dr. Quertermous completed clinical training in cardiology at the Massachusetts General Hospital and research training in molecular genetics in the Department of Genetics at the Harvard Medical School. Dr. Quertermous established an independent laboratory in the Cardiac Unit at the Mass General in 1987. He was recruited to Vanderbilt University in 1991 as Chief of Cardiology and Professor of Medicine and Molecular Physiology and Biophysics. Dr. Quertermous moved to Stanford University in 1997 where he assumed leadership of the Division of Cardiovascular Medicine. Research in the Quertermous laboratory has employed genetic approaches for the study of vascular disease as a primary research focus. Currently, research in the Quertermous laboratory employs large-scale human genetics studies to better understand the genetic basis of atherosclerosis, and related risk factors such as hypertension and insulin resistance. Ongoing efforts include genome-wide association studies in multiethnic cohorts with coronary heart disease, and these efforts are integrated with other worldwide efforts aimed at conducting definitive association based analyses. Variation identified through these studies is further investigated at the molecular level to better understand the basic mechanisms of atherosclerotic heart disease.