Amgen Commences Registered Exchange Offer for Its Senior Floating Rate Notes Due 2008, 5.85 Percent Senior Notes Due 2017 and 6.375 Percent Senior Notes Due 2037| Amgen

Amgen Commences Registered Exchange Offer for Its Senior Floating Rate Notes Due 2008, 5.85 Percent Senior Notes Due 2017 and 6.375 Percent Senior Notes Due 2037

THOUSAND OAKS, Calif.--(BUSINESS WIRE)--Jan. 17, 2008--Amgen (NASDAQ:AMGN) today announced offers to exchange (1) any and all of its $2,000,000,000 Senior Floating Rate Notes due 2008 for an equal amount of new Senior Floating Rate Notes due 2008, (2) any and all of its $1,100,000,000 5.85 percent Senior Notes due 2017 for an equal amount of new 5.85 percent Senior Notes due 2017, and (3) any and all of its $900,000,000 6.375 percent Senior Notes due 2037 for an equal amount of new 6.375 percent Senior Notes due 2037.

The terms of the new notes are substantially the same as the original notes, except that the new notes will have no transfer restrictions under the Federal securities laws, rights to additional interest or registration rights. Original notes that are not exchanged will continue to be subject to transfer restrictions under the Federal securities laws.

The exchange offer will expire at 5:00 p.m., Eastern Time, on Feb. 19, 2008, unless extended. Tenders of the original notes must be made before the exchange offer expires and may be withdrawn at any time before the exchange offer expires.

Amgen urges holders of the original notes to read its exchange offer materials, including the prospectus and related materials, because they contain important information about the exchange offer. Holders of the original notes may obtain the prospectus and related materials through the exchange agent for the exchange offers, which can be contacted at:

The Bank of New York
101 Barclay Street - 7 East
New York, New York 10286
Attention: Carolle Montreuil,
Corporate Trust Operations,
Reorganization Unit
Telephone: (212) 815-5920
Facsimile: (212) 298-1915

This press release does not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of the securities to be issued in the exchange offer in any State in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such State.

Forward-Looking Statements

This news release contains forward-looking statements that involve significant risks and uncertainties, including those discussed below and others that can be found in our registration statement and prospectus relating to the exchange offer described above, in our Form 10-K for the year ended Dec. 31, 2006, and in our periodic reports on Form 10-Q and Form 8-K. Amgen is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise.

No forward-looking statement can be guaranteed and actual results may differ materially from those we project. Amgen's statements in this press release contain forward-looking statements regarding the timing of the exchange offer. There can be no assurance that Amgen will complete the exchange offer on the anticipated terms or at all. Amgen's ability to complete the exchange offer will depend, among other things, on market conditions. In addition, Amgen's results may be affected by our ability to successfully market both new and existing products domestically and internationally, clinical and regulatory developments (domestic or foreign) involving current and future products, sales growth of recently launched products, competition from other products (domestic or foreign) and difficulties or delays in manufacturing our products. In addition, sales of our products are affected by reimbursement policies imposed by third-party payors, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international trends toward managed care and health care cost containment as well as U.S. legislation affecting pharmaceutical pricing and reimbursement. Government and others' regulations and reimbursement policies may affect the development, usage and pricing of our products. Furthermore, our research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. We or others could identify safety, side effects or manufacturing problems with our products after they are on the market. Our business may be impacted by government investigations, litigation and product liability claims. Further, while we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors. We depend on third parties for a significant portion of our manufacturing capacity for the supply of certain of our current and future products and limits on supply may constrain sales of certain of our current products and product candidate development. In addition, we compete with other companies with respect to some of our marketed products as well as for the discovery and development of new products. Discovery or identification of new product candidates cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate will be successful and become a commercial product. Further, some raw materials, medical devices and component parts for our products are supplied by sole third-party suppliers.

About Amgen

Amgen discovers, develops and delivers innovative human therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first companies to realize the new science's promise by bringing safe and effective medicines from lab, to manufacturing plant, to patient. Amgen therapeutics have changed the practice of medicine, helping millions of people around the world in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. With a deep and broad pipeline of potential new medicines, Amgen remains committed to advancing science to dramatically improve people's lives. To learn more about our pioneering science and our vital medicines, visit

CONTACT: Amgen, Thousand Oaks
David Polk, 805-447-4613 (media)
Arvind Sood, 805-447-1060 (investors)