Amgen Announces New Data Highlighting Global Trends In Hip Fracture Incidence And Treatment

Real-World Data Reinforces Hip Fracture as a Significant Public Health Issue Globally, With Low Use of Pharmacologic Interventions
Results Presented as a Late-Breaking Abstract at the American Society for Bone and Mineral Research 2021 Annual Meeting (ASBMR)

THOUSAND OAKS, Calif., Oct. 4, 2021 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced results from real-world data in Asia, Europe, Oceania, and North and South America on the temporal trends in hip fracture incidence, and in post-fracture pharmacological treatment intervention. The study, presented as a late-breaking abstract at the American Society for Bone and Mineral Research 2021 Annual Meeting (ASBMR), is titled "Hip Fractures: Initial Report of Trends in Incidence, Treatment, and Mortality In Multiple Countries Using a Common Analytical Platform." The results of the study reveal that hip fracture remains a significant public health issue across the globe, and that the effects of aging populations and suboptimal pharmacological treatment may contribute to an increasing burden of osteoporosis.

"Hip fractures represent a major public health crisis, but previously available reports on incidence are based on decades old data for some regions," said Darryl Sleep, M.D., senior vice president of Global Medical and chief medical officer at Amgen. "We are excited to present the latest global data on hip fractures, which uses a unified methodology that makes it possible to provide updated incidence, as well as valuable insights on the risk factors and next steps in the treatment of osteoporosis."

This study, led by the University of Hong Kong, was funded by Amgen and includes Amgen authors. This initial report, inclusive of years 2005 and 2018, is based on thirteen data sources from Australia, Canada, Germany, Hong Kong, Italy, the Netherlands, New Zealand, South Korea, Spain, Taiwan, United Kingdom, and two systems (Medicare and Optum's de–identified Clinformatics® Data Mart Database) from the United States.i The change in age-standardized hip fracture incidence varied from -2.1% to +2.3% per year across all data sources (HK, -2.1%; UK, -1.3%; TW, -1.8%; IT, -1.4%; Spain, -1.1%; USM, -1.1%; Canada, -0.9%; NZ, -0.8%; USO, -0.2%; AU, +0.2%; GE, +0.8%; SK, +0.8%; NL, +2.3%); those data sources with full population coverage show the absolute number of hip fractures per year has increased. Post-fracture care with pharmacological treatment within 12 months after fracture ranged from 11.5% to 50.3% across the globe, with recent annual trends notably decreasing in some health care systems (e.g. United States Medicare).i

"This study examined patients over 50 years old who were hospitalized due to a hip fracture. Although hip fracture incidence has been stabilized or reduced in many countries in recent years, this reduction is insufficient to offset the increase of hip fractures as the global population ages," said lead investigator, Chor-Wing Sing, PhD, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong. "The current results also show low post-hip fracture treatment rates, which suggest that prevention efforts following hip fractures can be improved. Such efforts are critical, given that following a hip fracture, postmenopausal women are 2.5 times more likely to break another bone." ii

About Osteoporosis-related Fractures
Worldwide, one in three women and one in five men over the age of 50, will suffer a fracture due to osteoporosis.iii Similarly, in the U.S. one in two women over the age of 50 will experience a fracture in her remaining lifetime due to osteoporosis.iv Breaking a bone can be a life-altering event that can lead to pain, loss of mobility and a change in lifestyle.v

About Amgen
Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

Amgen Forward-Looking Statements
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i Sing C, Lin T, Bartholomew S, et al. Hip Fractures: Initial Report of Trends in Incidence, Treatment, and Mortality In Multiple Countries Using a Common Analytical Platform. Abstract presented at: American Society for Bone and Mineral Research Annual Meeting, October 1-4, 2021; San Diego, California.
ii Klotzbuecher CM, Ross, PD, Landsman, PB, et al. Patients with Prior Fractures Have an Increased Risk of Future Fractures: A Summary of the Literature and Statistical Synthesis. JBMR. 2010; 15:4, 721-739.
iii International Osteoporosis Foundation. Facts and Statistics. Accessed September 7, 2021.
iv National Osteoporosis Foundation. Osteoporosis Fast Facts. Accessed September 17, 2021.
v Cosman F, De beur SJ, Leboff MS, et al. Clinician's Guide to Prevention and Treatment of Osteoporosis. Osteoporos Int. 2014;25(10):2359-2381.

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